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De Architectura is a textbook of Roman architecture and engineering by Vitruvius which was rediscovered in 1414 and published in 1486. It became very influential and played a key role in the development of architecture as a scientific discipline and on an architecture based on Roman style and principles. The architecture by Palladio, which was popular all over Europe, was based on the work of Vitruvius.
The Romans were keen on building constructed on precise proportions and symmetry and that these proportions should be related to the human proportions. Vitruvius also studied human proportions and produced canons regarding this. Leonardo’s Vitruvian Man encoded these canons.
During Leonardo’s life Greek influence of the Italian Renaissance was not very widespread yet. It is known that he frequented the Garden of the Piazza San Marco which was a Neo-Platonic academy in Florence which attracted artists and poets as well as philosophers.