I assume you are referring to Darius the third. Darius III formed paranoia over the years, and by the time Alexander invaded, he was crazy. He suspected many of his generals of treason. For instance, when one general made a tactical retreat, Darius III suspected him of turning on his nation and had him killed. Four of the seven major generals of Persia were killed by Darius, crippling the Empire’s military movement. By the time Darius III died, much of the organization had collapsed, due to his mental illness. With no organized government, the provinces of Persia governed themselves. During this period, however, there were many self proclaimed kings, such as Alexander, Bessus, Smerdis, etc. However, none actualy managed to take a hold over the Empire, only over the city they resided in.

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However, Persia soon recovered, and around 247 BC, the empire re-emerged under the Parthian dynasty.

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